Understanding Diagnosis and Management of Psoriasis from Pages of History to Modern Era

Abstract

ABSTRACT: Objective To provide a current and informative description of psoriasis diagnosis and treatment from historical accounts to the present day. Methodology From the study's commencement until March 1, 2022, data were gathered from Embase, Web of Science, PubMed, and the Cochrane Library. The primary focus was on searching for pertinent meta-analyses, randomized controlled trials, systematic reviews, and observational studies regarding the diagnosis and treatment of psoriasis. Results and Conclusion Psoriasis is a long-term inflammatory disease affecting multiple systems, mostly affecting the skin and joints. The disease is recognized from ancient times. It may affect social functioning and interpersonal relationships of patients. Psoriasis is a systemic inflammatory disease that has several co-morbidities. The diagnosis is primarily clinical and a skin biopsy is seldom required. Depending on the severity of disease, appropriate treatment can be initiated including topical treatments like corticosteroids, topical retinoids, salicylic acid; phototherapy including UVB, PUVA along with systemic medications like oral retinoids, methotrexate, cyclosporine. Biologic Therapies are required for treatment for some patients who do not respond to above treatment. Systemic immunomodulatory drugs like Apremilast and JAK Inhibitors are also used. For most of the cases combined therapy along with life style modifications give promising results.