Identification of canine parvovirus with the Q370R point mutation in the VP2 gene from a giant panda (Ailuropoda melanoleuca)

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Abstract

Background: In this study, we sequenced and phylogenetic analyses of the VP2 genes from twelve canine parvovirus (CPV) strains obtained from eleven domestic dogs and a giant panda (Ailuropoda melanoleuca) in China. A novel canine parvovirus (CPV) was detected from the giant panda in China. Results: Nucleotide and phylogenetic analysis of the capsid protein VP2 gene classified the CPV as a new CPV-2a type. Substitution of Gln for Arg at the conserved 370 residue in CPV presents an unusual variation in the new CPV-2a amino acid sequence of the giant panda and is further evidence for the continuing evolution of the virus. Conclusions: These findings extend the knowledge on CPV molecular epidemiology of particular relevance to wild carnivores. © 2013 guo et al.; licensee BioMed Central Ltd.

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Guo, L., Yang, S. L., Chen, S. J., Zhang, Z., Wang, C., Hou, R., … Yan, Q. G. (2013). Identification of canine parvovirus with the Q370R point mutation in the VP2 gene from a giant panda (Ailuropoda melanoleuca). Virology Journal, 10. https://doi.org/10.1186/1743-422X-10-163

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