Stem Cell Therapies for Chronic Liver Diseases: Progress and Challenges

17Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

Abstract

Chronic liver diseases have become a significant health issue worldwide and urgently require the development of novel therapeutic approaches, in addition to liver transplantation. Recent clinical and preclinical studies have shown that cell-based therapeutic strategies may contribute to the improvement of chronic liver diseases and offer new therapeutic options to restore liver function through their roles in tissue impairment and immunomodulation. In this review, we summarize the current progress and analyze the challenges for different types of cell therapies used in the treatment of chronic liver diseases currently explored in clinical trials and preclinical studies in animal models. We also discuss some critical issues regarding the use of mesenchymal stem cells (MSCs, the most extensive cell source of stem cells), including therapeutic dosage, transfusion routine, and pharmacokinetics/pharmacodynamics (PK/PD) of transfused MSCs.

Cite

CITATION STYLE

APA

Li, T. T., Wang, Z. R., Yao, W. Q., Linghu, E. Q., Wang, F. S., & Shi, L. (2022). Stem Cell Therapies for Chronic Liver Diseases: Progress and Challenges. Stem Cells Translational Medicine, 11(9), 900–911. https://doi.org/10.1093/stcltm/szac053

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free