Pharmacokinetics of combined intraperitoneal and incisional lidocaine in the dog following ovariohysterectomy

Abstract

Topical application of local anesthetics provides safe analgesia following abdominal surgery in people. Conservative doses have been utilized to avoid toxicity. Toxic effects are proportional to amount of drug administered and the plasma concentration of the drug, allowing predictions of safety following pharmacokinetic studies. The maximum plasma level, the pharmacokinetics and the safety of lidocaine hydrochloride when administered by the combined intraperitoneal(8 mg/kg i.p. withepinephrine 1:400 000) and incisional (2 mg/ kg with epinephrine 1:200 000) routes were studied in six mixed breed dogs following ovariohysterectomy. Rapid uptake of lidocaine produced a peak concentration of 1.45 ± 0.36 μg/mL (mean ± SD. range 0.80-1.86 μg/mL) by 0.37 ± 0.26 h (range 0.11-0.81) after administration. The absorption half-life was 0.13 ± 0.1 h. Plasma concentrations decreased rapidly and the elimination half-life was 1.17 ± 0.11 h. No signs of toxicity were observed in these dogs in the 18 h following drug administration. The dose studied generated levels of lidocaine well below toxic.