SAT0061 Haq score is an independent predictor of sustained remission in patients with rheumatoid arthritis

Abstract

791 selected for outcome analyses. Among seropositive patients, both LDA and remission were less frequently achieved in case of RF-positivity. Relevantly, in ACPA-positive patients (n=273), the co-occurrence of RF dose-dependently influenced clinical outcomes. After 6 months of treatment, LDA and disease remission were achieved respectively by 69.6% and 47.8% of single ACPA-positive, 68.8% and 37.5% of ACPA-positive RF-low, and 57% and 27.6% of ACPA-positive RF-high patients (chi-square for trend p=0.18 for LDA, p=0.05 for remission). After adjusting for confounders (age, gender, symptoms' duration, baseline disease activity, use of prednisone, recruitment period), high levels of RF independently predicted failure to achieve LDA with an HR (95% CI) of 0.61 (0.39 to 0.95) and failure to achieve remission with an HR (95% CI) of 0.63 (0.35 to 0.99) (Figure 1). In contrast, ACPA levels did not show any significant predictive value, neither for thresholds of >3 ULN nor of >100 U. Conclusions: Among ACPA-positive RA patients, disease characteristics may vary in association with the extent of overall humoral autoimmunity. In particular, the concomitant presence of high levels of IgM RF seems associated with lower response rates to csDMARDs. Collectively, these findings highlight the importance of further subclassifying patients with autoantibody-positive RA in order get deeper insights into disease mechanisms and clinical outcomes. References: [1] Aletaha D et al.