A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer

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Abstract

Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.

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Hubert, C. G., Stauffer, S. R., & Lathia, J. D. (2023). A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer. PLoS Biology, 21(9 September). https://doi.org/10.1371/journal.pbio.3002295

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