The Effect of Asphyxia on Neonatal Death: A Meta-Analysis

Abstract

Background: Asphyxia is the second leading cause of neonatal death in the world. The indicator for the diagnosis of asphyxia in newborns is the APGAR (Appearance, Pulse, Grimace, Activity, and Respiration) score. APGAR score at the fifth minute of life correlated with the asphyxia degree. This study aimed to estimate how great the effect of asphyxia on neonatal death based on the results of some previous studies. Subjects and Method: This was a systematic and meta-analysis study. The articles used in this study were obtained from several databases including PubMed, Science Direct, and Google Scholar. The articles used in this study were articles that have been published from 2010-2020. The article was searched by considering the eligibility criteria defined using the PICO model. The population of this study was neonatal with intervention in the form of asphyxia, comparison, namely non-asphyxia, and outcome in the form of death. These articles were collected for 1 month. The keywords were "neonatal" AND "asphyxia" OR "APGAR score" AND "mortality", "death neonatal asphyxia" OR "mortality asphyxia" AND "cross sectional". The articles included in this study were full-text articles with a crosssectional study design. The articles were collected using PRISMA flow diagrams. The articles were analyzed using the Review Manager 5.3 application. Results: 6 articles were reviewed in this study. This study showed that asphyxia increased the risk of neonatal death (aOR= 3.52; 95% CI= 1.05 to 11.82; p=0.040). Conclusion: Asphyxia increases the risk of neonatal death.