Photocleavable dimerizer for the rapid reversal of molecular trap antagonists

Abstract

Background: The ability to rapidly turn on and off an acute antagonist is helpful to understand the initiation of a cellular program. Results: Aphotocleavable analog was produced and functionally demonstrated. Conclusion: Fine temporal control of endosome dispersion and restoration was obtained. Significance: The combination of traps and the photocleavable analog permits new avenues to study signaling within a single cell in an organism. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.