Anti-Inflammatory Effects of β-Glucan in Cancer Related Fatigue

Abstract

Immune-mediated inflammatory diseases are among the exhausting diseases which are often difficult to diagnose. Fatigue is the most common syndrome accompanying cancer diseases and treatment. In cancer patients, fatigue is not only a manifestation of treatment, but also reflects biological effects of the tumor. The combination of several factors, particularly endocrinic, hematological, metabological and detoxification strain, is connected with the acute inflammatory response. In our study, we evaluated the possible effects of supplementation with β-glucan on serum levels of CRP, SAA, orosomucoid and prealbumin. We found a decrease in CRP, SAA and orosomucoid levels after 60 days of β-glucan treatment. Glucan not only suppressed inflammatory manifestations, but also improved patient's conditions.