Anti-microbial and anti-inflammatory activity of new 4-methoxy-3-(Methoxymethyl) phenol and (E)-N'-(5-bromo-2-methoxybenzylidene)-4-methoxy benzohydrazide isolated from calotropis gigantean white

Abstract

A new phenol and hydrazide derivatives were obtained for the first time from the C. giganteawhite by silica gel column chromatography. The structure of the isolated compounds was identified by UV, IR NMR and MS. C. gigantea was scientifically reported for several medicinal properties viz. analgesic, antimicrobial and cytotoxic. In this screening work, anti-microbial activity of test compounds was found to be active against all organisms. Additionally, anti-inflammatory activity of the test groups has reduced the thickness of edema of the hind paw compared to the control group.