An initial case of suppressed restenosis with nuclear factor-kappa B decoy transfection after percutaneous coronary intervention

Abstract

Background: Nuclear factor-kappa B (NF-κB) is well known for playing a pivotal role in restenosis after percutaneous coronary intervention (PCI). Methods and Results: This is the first report to demonstrate an effect of NF-κB decoy oligodeoxynucleotides (ODN) to prevent restenosis after PCI after a 4-year observation using a coronary computed tomography (CT) scan. We showed that the decoy treatment suppressed neointimal formation after stent implantation compared to that in the same artery. Conclusion: Thus, for the first time, we demonstrate the clinical usefulness of the CT scan to reveal the effects of NF-κB decoy ODN transfer after PCI. Copyright © 2008 John Wiley & Sons, Ltd.