EXploring Aging Interventions in Human Brain Organoids

Abstract

Aging is a progressive physiological degeneration and represents the most important risk factor for the development of multiple human neurodegenerative disorders [1). Therefore, determining the molecular drivers of aging is fundamental to understand brain aging comorbidities. Importantly, current evidence indicates that the progressive accumulation of senescent cells strongly contributes to brain degeneration and organismal aging [2].