A new C-methyl isoflavone and other compounds from the roots of Amphiblemma monticola (Melastomataceae)

Abstract

The phytochemical study of the EtOH extract of the roots of Amphiblemma monticola Jacq.-Fél. led to the isolation of a new C-methyl isoflavone, amphiblemmone A (1), along with ten known compounds, including 3,4′-di-O-methylellagic acid (2), dimethyl 4,4′,5,5′,6,6′- hexahydroxybiphenyl-2,2′- dicarboxylate (3), lupeol (4), ellagic acid (5), β-sitosterol (6), sitosterol 3-O-β-D-glucopyranoside (7), 3-hydroxy-4,5-dimethoxybenzoic acid (8), 3-Omethylellagic acid 4′-O-β-D-xylopyranoside (9), and a mixture of oleanolic acid (10) and ursolic acid (11). The structures were elucidated using spectroscopic analyses (IR, UV, NMR and MS) and comparison with literature data. Compounds 2-11 were isolated for the first time from the genus Amphiblemma. This is the first report of compounds 2-4, 8 and 9 from the Melastomataceae family.