Triazolopyridines. Part 30.1 Hydrogen transfer reactions; Pyridylcarbene formation

Abstract

The transfer hydrogenation reaction of [1,2,3]triazolo[1,5-a]pyridines with Pd/C/Zn or Pd(OH)2/C/Zn in water, ethanol or water/ethanol mixture has been explored. 4,5,6,7-Tetrahydrotriazolopyridines were obtained in good to medium yields. In addition, under the same conditions 2-substituted pyridines were also formed as a result of intermediate pyridylcarbene formation, by triazole ring opening and loss of nitrogen. © ARKAT-USA, Inc.