IgG anti IgG antibodies in rheumatoid arthritis and certain other conditions

Abstract

A modified technique of immunoadsorption and a new simple latex test used for the detection of serum IgG anti IgG antibodies are described. The latex test is both specific and reproducible. 38 subjects with rheumatoid arthritis, 30 with osteoarthritis, 19 with hepatitis, and 5 with primary biliary cirrhosis, and 12 healthy adults were examined for serum IgG anti IgG antibody. The highest titers were found in the rheumatoid arthritis group; the geometric mean titer being 1:79. The geometric mean titers in the osteoarthritis and hepatitis groups were both 1:27 and in healthy adult controls 1:15. The possible significance of serum IgG anti IgG antibodies in these various groups is discussed.