Chemical Synthesis, Spectral Characterization and Antitumor Activity of Co(II), Zn(II) and Ni(II) Complexes Derived from Thiazole-based Schiff Base Ligand

Abstract

The present study deals with the synthesis of a new Schiff base ligand, 4-(((4-chlorobenzo[d]thiazol-2-yl)imino)methyl)-2-methoxyphenol (HL) derived from the condensation of 2-Amino-4-chlorobenzothiazole and 4-Hydroxy-3-methoxybenzaldehyde, and its Co(II), Zn(II) and Ni(II) complexes in 2:1 molar ratio (2HL:M). The Schiff base ligand and its metal complexes were characterized using FT-IR, UV-Visible absorption, mass spectra, and TGA techniques. The spectral analysis results confirmed the molecular structures of the Schiff base ligand and its metal complexes. Further, the metallic Schiff base complexes showed significant growth inhibition in the adenocarcinoma human alveolar basal epithelial cells, A549, with the Co(II), Zn(II), and Ni(II) complexes having IC50 values of 40.78, 42.04, and 44.69 M, respectively.