Emergence of carbapenem-resistant Salmonella Mbandaka through IS 26 -driven bla NDM-1 mobilization and chromosomal structural variation

Abstract

As a clinically significant foodborne pathogen, carbapenem-resistant Salmonella presents a significant therapeutic challenge due to its extensive antibiotic resistance. While bla NDM-1 is conventionally plasmid-borne, our study elucidates its transfer between chromosomes and a conjugative IncC plasmid in Salmonella . Our findings demonstrate the pivotal involvement of IS 26 and IS CR1 mobile genetic elements in orchestrating genomic rearrangements while concurrently mediating the horizontal transfer and subsequent amplification of antimicrobial resistance determinants. This study provides an important theoretical basis for an in-depth analysis of the horizontal transfer mechanism of bacterial resistance genes.