Synthesis and bioactivity of N-(5-aryl-1,3,4-oxadiazol-2-yl)-substituted amides.

Abstract

Acylation of 2-amino-5-aryl-1,3,4-oxadiazoles with acyl chlorides and trichloroacetic acid gave eleven new N-[5-aryl-1,3,4-oxadiazol-2-yl]-substituted amides. The required oxadiazole precursors were prepd. by oxidative cyclization of corresponding aldehyde semicarbazones. The structures of the synthesized compds. were elucidated by elemental anal., 1HNMR, IR and MS. They were screened for their larvicidal activities against wild fruit and antibiotic activities. [on SciFinder(R)]