Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones

Abstract

C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8- ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.