An 11-year-old male patient with the deletion of IKZF1 (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(BCR-ABL1) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate. The patient recovered completely after therapy. However, intracranial hemorrhage (ICH) occurred following oral methotrexate at a dose of 25 mg/ m2 in maintenance treatment, and he had neurological sequelae including hemiplegic paralysis.
CITATION STYLE
Xin, N., Fen, Z., Li, C., Yan, X., & Runming, J. (2019). Intracranial hemorrhage following oral low-dose methotrexate after multiple toxicities caused by high-dose methotrexate in childhood acute lymphoblastic leukemia. Frontiers in Pharmacology, 10. https://doi.org/10.3389/fphar.2019.01072
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