When It Comes to CTL Recognition, Size Does Matter

Abstract

As long ago as the early 1970s, more than a decade before the study by Townsend et al. ([1][1]) at Oxford that is showcased in this issue, Doherty and Zinkernagel ([2][2]) discovered that CTLs recognize H-2 Ags that have been altered in some way by viral infection. What may seem curious is that it