Bioactive phenylethanoids and coumarines from basalmocitrus cameroonensis

Abstract

Two new phenylethanoids, basalefhanoid A (1) and B (2), and one new ceramide, basalamide A (3), together with eleven known compounds (4-14) were isolated from the MeOH extract of the stem barks of Basalmocitrus cameroonensis. The structures of all compounds were determined by comprehensive analyses of their ID and 2D NMR, mass spectral (EI and ESI) data, chemical reactions, and comparison with previously known analogs. Compounds 1, 2, 5, and 7-10 demonstrated a strong inhibition on reactive oxygen species (ROS) production in the oxidative burst activity of whole blood on activation with serum opsonized zymosan in the range of IC50 = 0.06- 12.30 μg mL -1.© 2009 Veriag der Zeitschrift fur Natürforschung.