Clinicopathological characteristics of chordoma: An institutional experience and a review of the literature

Abstract

Aim: To study the clinicopathologic characteristics of chordomas from a single institution. Ma terIal and Methods: This study is a retrospective analysis of 18 cases of chordomas diagnosed over a period of 5-years at Sher-i-Kashmir Institute of Medical Sciences, Srinagar, from 2006 to 2010. Results: The overall mean age of the patients was 46.72 years. Males outnumbered females. Sacrum was the commonest site involved. Histopathologically, the majority of cases were conventional chordoma with four cases of chondroid variety. There was a single case of dedifferentiated chordoma that presented with bone metastasis. Most patients did well after surgery and radiotherapy. One patient had a local recurrence and one patient with dedifferentiated variant died on follow-up. ConclusIon: Though locally aggressive, chordomas are effectively treated with resection and postoperative radiotherapy.