Phytoconstituents and biological activities of Panax vietnamensis (Vietnamese ginseng): A precious ginseng and call for further research-a systematic review

Abstract

Panax vietnamensis Ha et Grushv., a Vietnamese ginseng, is a well-known plant, naturally distributed in the Ngoc Linh and Hoang Lien Son mountain areas in Vietnam. It is used as a tonic and medicinal food in traditional folk medicine because it possesses wondrous health benefits. To support its functional attributes, various investigations have been carried out to find out its anti-inflammatory, anti-cancer, anti-stress, anti-nociception, psychomotor and sedativehypnotic effects and anxiolytic activities. Also similar to other ginsengs, Vietnamese ginseng is a rich source of saponins and it has higher content of protopanaxadiol-, protopanaxatrial- and ocotillol-type saponins compared to other ginsengs in the world. Majonoside R2 is a main saponin in Vietnamese ginseng but this compound does not exist in Panax ginseng. Based on this systematic review, we discussed for future prospects and suggest that thorough scientific scrutiny is necessary in future researches.