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Synthesis of oxazocenones via gold(I)-catalyzed 8- endo -dig hydroalkoxylation of alkynamides

Organic Letters (2015) 17(3) 418-421
DOI: 10.1021/ol503273v
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Abstract

Several benzoxazocenones have been found to exhibit novel cellular activities. In the present study, we report a gold(I)-catalyzed 8-endo-dig hydroalkoxylation reaction of alkynamides to access analogous oxazocenone scaffolds. This methodology provided an advanced intermediate, which was elaborated to a des-benzo analog of a bioactive benzoxazocenone.

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APA

Scully, S. S., Zheng, S. L., Wagner, B. K., & Schreiber, S. L. (2015). Synthesis of oxazocenones via gold(I)-catalyzed 8- endo -dig hydroalkoxylation of alkynamides. Organic Letters, 17(3), 418–421. https://doi.org/10.1021/ol503273v

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