Studies on marine microorganisms. V: A new antibiotic, aplasmomycin, produced by a streptomycete isolated from shallow sea mud

Abstract

A new antibiotic, aplasmomycin, which inhibits growth of Gram-positive bacteria including mycobacteria in vitro, and plasmodia in vivo was obtained from a strain of Streptomyces griseus isolated from shallow sea sediment in Sagami Bay. The antibiotic forms colorless needle-like crystals and has a molecular formula of C41H60O14Na. Based on its physical and chemical properties, aplasmomycin was concluded to be a new antibiotic. The antibiotic was produced in selected media devised to relate to a marine environment. © 1976, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.