Single-cell RNA sequencing (scRNA-seq) provides an unprecedented view of cellular diversity of biological systems. However, across the thousands of publications and datasets generated using this technology, we estimate that only a minority (25%) of studies provide celllevel metadata information containing identified cell types and related findings of the published dataset. Metadata omission hinders reproduction, exploration, validation, and knowledge transfer and is a common problem across journals, data repositories, and publication dates. We encourage investigators, reviewers, journals, and data repositories to improve their standards and ensure proper documentation of these valuable datasets.
CITATION STYLE
Puntambekar, S., Hesselberth, J. R., Riemondy, K. A., & Fu, R. (2021). Cell-level metadata are indispensable for documenting single-cell sequencing datasets. PLoS Biology, 19(5). https://doi.org/10.1371/journal.pbio.3001077
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