Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases

Abstract

Objectives: Cardioankle vascular index (CAVI) is a new index of arterial stiffness independent of immediate blood pressure. Homocysteine (Hcy) is an independent risk factor for vascular diseases. The aim of this study was to investigate the relationship between Hcy and CAVI in the vascular-related diseases. Design: Descriptive research. Participants: 88 patients (M/F 46/42) with or without hypertension, coronary artery disease or arteriosclerosis obliterans were enrolled to our study. They were divided into two groups according to the level of Hcy. Methods: CAVI, carotid-femoral pulse wave velocity (CFPWV) and carotid-radial pulse wave velocity (CR-PWV) were measured by VS-1000 and Complior apparatus. Results: There was significant correlation between Hcy and CF-PWV, CR-PWV, CAVI in the entire group (r=0.33, p=0.002; r=0.51, p<0.001; r=0.42, p<0.001, respectively). And there was significant correlation between Hcy and CF-PWV, CR-PWV, CAVI in the vascular-related disease group (r=0.23, p=0.048; r=0.51, p<0.001; r=0.392, p=0.001, respectively). The level of Hcy was significantly higher in patients with one or more vascular diseases than in patients without vascular diseases. The levels of CF-PWV, CR-PWV and CAVI were significantly higher in Hcy =15 μmol/l group than in Hcy <5 μmol/l group (13.7±3.0 vs 10.8±2.5, p < 0.001; 10.6 ±2.1 vs 9.2±1.6, p=0.001; 9.30±2.1 vs 7.79±2.1, p=0.001, respectively). Multiple linear regression showed that Hcy, body mass index (BMI) and age were independent associating factors of CAVI in the entire study group (β=0.421, p=0.001; β=-0.309, p=0.006; β=0.297, p=0.012, respectively). And Hcy, BMI and age were independent influencing factors of CAVI in the vascular-related disease group (β=0.434, p=0.001; β= -0.331, p=0.009; β=0.288, p=0.022, respectively). Conclusions: CAVI was positively correlated with Hcy in the vascular-related diseases.