Discovery of α-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharmacokinetic properties

Isaac E. Marx; Erin F. DiMauro; Alan Cheng; Renee Emkey; Stephen A. Hitchcock; Liyue Huang; Ming Y. Huang; Jason Human; Josie H. Lee; Xingwen Li; Matthew W. Martin; Ryan D. White; Robert T. Fremeau; Vinod F. Patel

Journal Article

Discovery of α-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharmacokinetic properties

Bioorganic and Medicinal Chemistry Letters (2009) 19(1) 31-35

DOI: 10.1016/j.bmcl.2008.11.026

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Abstract

A series of α-amidosulfones were found to be potent and selective agonists of CB2. The discovery, synthesis, and structure-activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled. © 2008 Elsevier Ltd. All rights reserved.

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Marx, I. E., DiMauro, E. F., Cheng, A., Emkey, R., Hitchcock, S. A., Huang, L., … Patel, V. F. (2009). Discovery of α-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharmacokinetic properties. Bioorganic and Medicinal Chemistry Letters, 19(1), 31–35. https://doi.org/10.1016/j.bmcl.2008.11.026

Discovery of α-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharmacokinetic properties

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