The importance of angiogenic and antiangiogenic biomarkers in pathogenesis and early diagnosis of preeclampsia

Abstract

The early diagnosis of preeclampsia (PE) remains one of the great medical problems worldwide. PE is a multisystemic disorder and the etiology is still unclear. The equilibrium between anti-angionenic and angiogenic factors is essential in the PE pathogenesis. In this review, the authors highlight the role of key circulating anti-angionenic and antiangiogenic factors as pathogenic biomarkers and as well as early diagnostic biomarkers for PE. They analyzed the main anti-angiogenic factors: soluble FMS-like tyrosine kinase (sFlt-1), soluble endoglin (sEng), and the angiogenic factors - vascular endothelial growth factor (VEGF) and placental growth factor (P1GF). An accurate algorithm for diagnosing PE using only biomarkers is still absent.