Curative radiotherapy outcomes in elderly bladder cancer patients: A single-center experiences

Abstract

OBJECTIVE In this retrospective research, it was aimed to evaluate results of radiotherapy (RT) in elderly bladder cancer patients. METHODS A total of 47 patients who receiving RT or chemoradiotherapy treatment for bladder cancer in elderly patient (>70 years) were included in the study. RESULTS In total 47 patients, 4 patients (8.5%) had Stage I, 38 patients (80.8%) had Stage II, and 5 patients (10.6%) had Stage III bladder cancer. About 76.9% of patients had invasive urothelial, 3.8% of patients had squa-mous and micropapillary carcinoma, and 19.2% of had other (adenocarcinoma) histopathological type. Gender, age, family cancer history, hematuria, smoking, bladder carcinoma type, Charlson CoMorbidity Index, RT dose, concurrent chemoradiotherapy, metastasis side, acute and late toxicity, and follow-up duration of patients showed insignificant differences according to stage (p>0.05). We found that over-all survival and disease-free survival (DFS) were statistically significant according to the stages (p<0.05). DFS for Karnofsky Performance Status (KPS) >70 group (25.97±19.06) was higher than KPS <70 group (2.37±1.53) with statistically significant difference (p<0.05). CONCLUSION Curative RT and chemoradiotherapy can be safe regimen for older (>70 year) patients with bladder cancer. Nonetheless, KPS and geriatric assessments tools should be consideration before RT and chemoradio-therapy administration.