Improving tuberculosis diagnostics with biomarkers

Abstract

OBJECTIVE: To study the alkaloids of Voacanga africana.$\$nMETHODS: The alkaloids were isolated by normal phase silica gel and Sephadex LH-20 column chromatography. Their structures were elucidated by analysis of spectroscopic data.$\$nRESULTS: Eight alkaloids were isolated and their structures were elucidated as voacangine(1), voacangine hydroxyindolenine(2), 19R-epi-voacristine(3), epi-ibogaine(4), vobasine(5), 19-epi-heyneanine(6), vobtusine(7) and voacamine(8).$\$nCONCLUSION: Compounds 2-4 and 6 are isolated from this plant for the first time.