Comparative X-Ray and conformational analysis of a new crystal of 13α,21-dihydroeurycomanone with eurycomanone from eurycoma longifolia and their anti-estrogenic activity using the uterotrophic assay

Abstract

13,21-Dihydroeurycomanone (1), a known quassinoid of Eurycoma longifolia Jack was recrystallized from chloroform into a novel crystal structure in space group P21. Its Xray data were compared with those of eurycomanone (2). Following intraperioneal injections at similar doses of 2.44 μmol/kg/day for 3 consecutive days, 2 displayed comparable potency with tamoxifen but was more potent than 1 in the anti-estrogenic effect against 17-ethynylestradiol (EE)-induced uterotrophy of immature rats. © Georg Thieme Verlag KG Stuttgart.