Combining variables for cancer risk estimation: Is the sum better than the parts?

Abstract

Examining joint exposures of modifiable breast cancer risk factors may provide advantages over individual exposure–disease association analyses. Using the Healthy Lifestyle Index, Arthur and colleagues analyzed the joint impacts of diet, alcohol, smoking, physical activity, and obesity on breast cancer risk, and subtypes, in postmenopausal women enrolled in the Women's Health Initiative. The analysis provides data for population-attributable risk estimations and future prevention trials to target multiple risk factors. The public health messages for the individual risk factors remain unchanged, however, and it is still not clear whether improving one risk factor can counteract the adverse effects of another.