A migrating cell must establish front-to-back polarity in order to move. In this issue, Juanes-Garcia et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201407059) report that a short serine-rich motif in nonmuscle myosin IIB is required to establish the cell's rear. This motif represents a new paradigm for what determines directional cell migration.
CITATION STYLE
Fenix, A. M., & Burnette, D. T. (2015). A small part of myosin IIB takes on a big role in cell polarity. Journal of Cell Biology, 209(1), 11–12. https://doi.org/10.1083/jcb.201503079
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