Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis

37Citations
Citations of this article
23Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

p68 RNA helicase is a prototypical RNA helicase. Here we present evidence to show that, by interacting with Ca-calmodulin, p68 has a role in cancer metastasis and cell migration. A peptide fragment that spans the IQ motif of p68 strongly inhibits cancer metastasis in two different animal models. The peptide interrupts p68 and Ca-calmodulin interaction and inhibits cell migration. Our results demonstrate that the p68-Ca-calmodulin interaction is essential for the formation of lamellipodia and filopodia in migrating cells. p68 interacts with microtubules in the presence of Ca-calmodulin. Our experiments show that interaction with microtubules stimulates p68 ATPase activity. Further, microtubule gliding assays demonstrate that p68, in the presence of Ca-calmodulin, can function as a microtubule motor. This motor activity may allow p68 to transport Ca-calmodulin to the leading edge of migrating cells. © 2013 Macmillan Publishers Limited. All rights reserved.

References Powered by Scopus

Cell Migration: Integrating Signals from Front to Back

4075Citations
N/AReaders
Get full text

Calcium Signaling

3503Citations
N/AReaders
Get full text

Cellular motility driven by assembly and disassembly of actin filaments

3483Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer

269Citations
N/AReaders
Get full text

The DEAD box proteins DDX5 (p68) and DDX17 (p72): Multi-tasking transcriptional regulators

118Citations
N/AReaders
Get full text

DDX5 promotes proliferation and tumorigenesis of non-small-cell lung cancer cells by activating β-catenin signaling pathway

75Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Wang, H., Gao, X., Yang, J. J., & Liu, Z. R. (2013). Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis. Nature Communications, 4. https://doi.org/10.1038/ncomms2345

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

79%

Researcher 3

21%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 12

63%

Biochemistry, Genetics and Molecular Bi... 5

26%

Chemistry 1

5%

Medicine and Dentistry 1

5%

Article Metrics

Tooltip
Mentions
News Mentions: 1
Social Media
Shares, Likes & Comments: 1

Save time finding and organizing research with Mendeley

Sign up for free