Primary nasopharyngeal interdigitating dendritic cell tumor presentation and response to radiation therapy

Abstract

We report the case of a primary nasopharyn-s geal interdigitating dendritic cell tumor (IDDCT). A 25-year old male presented with bilateral decreased hearing, double vision, and ataxia. Flexible nasopharyngoscopy reviewed a large mass obstructing and illing the entire nasopharynx. MRI and PET-CT confirmed the f presence of the primary tumor and demonstrat-o ed bilateral cervical lymphadenopathy. Biopsy p of the nasopharynx revealed a hematolymphoid neoplasm with dendritic cell differentiation, l most consistent with an IDDCT. The lesion was e unresectable. The patient was treated with definitive radiotherapy to 66 Gy to the primarys tumor and 50 Gy to the bilateral cervical lym phatics using an IMRT technique. A complete response was achieved and the patient remains disease free at the primary site 23 months after completion of radiotherapy. © Copyright N.E. Dunlap et al., 2010.