Abstract
Chronic lymphocytic leukemia (CLL) is generally characterized by an indolent disease course. Histologic transformation (also known as Richter’s transformation) to more aggressive lymphomas, such as diffuse large B-cell lymphoma or Hodgkin lymphoma, occurs in approximately 2% to 10% of patients and is associated with a poor prognosis. These NCCN Guidelines Insights discuss the recommendations for the diagnosis and management of patients with histologic transformation.
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CITATION STYLE
Wierda, W. G., Byrd, J. C., Abramson, J. S., Bilgrami, S. F., Bociek, G., Brander, D., … Sundar, H. (2019). Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019. JNCCN Journal of the National Comprehensive Cancer Network, 17(1), 12–20. https://doi.org/10.6004/jnccn.2019.0002
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