Ovarian volume: A novel outcome predictor for assisted reproduction

Abstract

Objective: To determine the potential of ovarian volume as a predictor of assisted reproduction outcomes. Design: Retrospective chart review. Setting: University-based assisted reproduction program. Patients: One hundred eighty- eight women initiating their first cycle of assisted reproduction. Interventions: None. Main Outcome Measures: Pretreatment transvaginal ultrasound ovarian measurements were compared with subsequent ovulation induction parameters (peak E2, numbers of oocytes, and embryos) and cycle outcome (cancellation and pregnancy). Result: Total ovarian volume and volume of the smallest ovary were significant variables predicting peak E2 and numbers of oocytes and embryos. Total ovarian volume was a predictor of cycle cancellation and volume of the smallest ovary a predictor of clinical pregnancy. Large ovarian volumes are associated with good assisted reproductive technology outcomes whereas small ovarian volumes are associated with poor outcomes. Conclusion: Beyond maternal age, total ovarian volume, and volume of the smallest ovary are significant predictors of the success of assisted reproductive techniques.