Acid-base status of pregnant guineapigs during neuroleptanalgesia with diazepam and fentanyl-fluanisone

Abstract

Neuroleptanalgesia was induced in late pregnancy in guineapigs with diazepam and fentanyl-fluanisone. Hypotension occurred, but the arterial acid-base status after 45-60 min was near normal. When repeated injections of fentanyl-fluanisone were given to maintain neuroleptanalgesia, the blood pressure fell further and severe metabolic acidosis developed. Placental blood flow determined with radioactive microspheres was much lower during maintained neuroleptanalgesia than in guineapigs anaesthetized with diazepam and pentobarbitone. © 1983, Royal Society of Medicine Press. All rights reserved.