Atypical presentations of intracranial hypotension: Comparison with classic spontaneous intracranial hypotension

Abstract

BACKGROUND AND PURPOSE: Atypical clinical presentations of spontaneous intracranial hypotension include obtundation, memory deficits, dementia with frontotemporal features, parkinsonism, and ataxia. The purpose of this study was to compare clinical and imaging features of spontaneous intracranial hypotension with typical-versus-atypical presentations. MATERIALS AND METHODS: Clinical records and neuroimaging of patients with spontaneous intracranial hypotension from September 2005 to August 2014 were retrospectively evaluated. Patients with classic spontaneous intracranial hypotension (n=33; mean age, 41.7=14.3 years) were compared with those with intracranial hypotension with atypical clinical presentation (n=8; mean age, 55.9=14.1 years) and 36 controls (mean age, 41.4=11.2 years). RESULTS: Patients with atypical spontaneous intracranial hypotension were older than those with classic spontaneous intracranial hypotension (55.9=14.1 years versus 41.7=14.3 years; P