The brain has different responses to traumatic injury as a function of its developmental stage. As a model of injury to the immature brain, the piglet shares numerous similarities in regards to morphology and neurodevelopmental sequence compared to humans. This chapter describes a piglet scaled focal contusion model of traumatic brain injury that accounts for the changes in mass and morphology of the brain as it matures, facilitating the study of age-dependent differences in response to a comparable mechanical trauma.
CITATION STYLE
Munoz Pareja, J. C., Keeley, K., Duhaime, A. C., & Dodge, C. P. (2016). Modeling pediatric brain trauma: Piglet model of controlled cortical impact. In Methods in Molecular Biology (Vol. 1462, pp. 345–356). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3816-2_19
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