Practicing antimicrobial stewardship: De-escalating antibiotics in patients with acute myeloid leukemia and neutropenic fever

Abstract

We compared risk of recurrent fever in patients with acute myeloid leukemia undergoing induction chemotherapy with febrile neutropenia without an infectious source in which antibacterials were de-escalated before neutrophil recovery versus continued. There was less recurrent fever when antibacterials were de-escalated early with no increased adverse events.