Therapeutic outcome of nasopharyngeal carcinoma with cranial nerve palsy: A single institution experience of 104 patients

7Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

Abstract

Purpose: Cranial nerve (CN) palsy is the main symptom in patients with locally advanced nasopharyngeal carcinoma (NPC). This study aimed to evaluate the therapeutic outcome of NPC with CN palsy and to analyze the prognostic factors. Patients and methods: A total of 104 NPC patients with CN palsy curatively treated by conventional (n=44) or conformal (n=60) radiotherapy (RT) were enrolled. Upper CN palsy was present in 81 patients, lower CN palsy in four patients, and both upper and lower CN palsy in 19 patients. Forty-one patients had CN palsy for >2 months before diagnosis. Results: Complete recovery of CN palsy was observed in 74 patients. The actuarial 5-year locoregional control (LRC), distant metastasis-free survival (DMFS), and overall survival (OS) rates were 58.2%, 62.2%, and 38.4%, respectively. No significant difference was observed in CN recovery, LRC, DMFS, or OS for patients treated by conventional versus conformal technique. However, significant reduction of grade 3 or greater toxicities was found in those treated by the conformal technique (odds ratio =0.28). Conclusion: Patients with CN palsy presenting >2 months before diagnosis were hard to recover from palsy. The LRC, OS, and recovery from CN palsy did not significantly change with the treatment evolution. Patients with complete recovery from CN palsy had longer OS.

References Powered by Scopus

Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: Positive effect on overall and progression-free survival

702Citations
N/AReaders
Get full text

The national cancer data base report on the relationship of race and national origin to the histology of nasopharyngeal carcinoma

201Citations
N/AReaders
Get full text

Quality of Life and Survival Outcome for Patients With Nasopharyngeal Carcinoma Receiving Three-Dimensional Conformal Radiotherapy vs. Intensity-Modulated Radiotherapy-A Longitudinal Study

178Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Prognostic value of the Epstein-Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinoma

8Citations
N/AReaders
Get full text

Cranial neuropathies in advanced nasopharyngeal carcinoma: Neurological recovery after modern radiotherapy and systemic chemotherapy

5Citations
N/AReaders
Get full text

Multi-trajectories of health-related quality of life and their associated factors in patients with nasopharyngeal carcinoma: A longitudinal study

4Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Huang, C. C., Fang, F. M., Chen, H. C., Hsu, H. C., Huang, T. L., Su, Y. L., & Chang, Y. C. (2017). Therapeutic outcome of nasopharyngeal carcinoma with cranial nerve palsy: A single institution experience of 104 patients. OncoTargets and Therapy, 10, 2069–2075. https://doi.org/10.2147/OTT.S129653

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 6

86%

Professor / Associate Prof. 1

14%

Readers' Discipline

Tooltip

Medicine and Dentistry 7

64%

Nursing and Health Professions 3

27%

Pharmacology, Toxicology and Pharmaceut... 1

9%

Save time finding and organizing research with Mendeley

Sign up for free