Abstract
We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal accroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.
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Oberpichler, H., Sauer, D., Roßberg, C., Mennel, H. D., & Krieglstein, J. (1990). PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus. Journal of Cerebral Blood Flow and Metabolism, 10(1), 133–135. https://doi.org/10.1038/jcbfm.1990.17
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