Abstract
Background: RWD is a conserved domain in human proteome with unknown function. Results: We solved the crystal structure of an RWD domain in complex with a Ubc9 homodimer and conducted a biochemical investigation. Conclusion: The RWD domain binds to a Ubc9 surface that also must interact with E1, E3, and SUMO. Significance: This study establishes a function for the evolutionary conserved RWD domain.
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CITATION STYLE
APA
Alontaga, A. Y., Ambaye, N. D., Li, Y. J., Vega, R., Chen, C. H., Bzymek, K. P., … Chen, Y. (2015). RWD domain as an E2 (Ubc9)-interaction module. Journal of Biological Chemistry, 290(27), 16550–16559. https://doi.org/10.1074/jbc.M115.644047
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