Urinary pseudouridine excretion in myelomatosis

Abstract

Urinary ψ excretion is independent of the main indices of tumour activity in myelomatosis (serum paraprotein, serum β2-microglobulin, serum creatinine and urinary light chain production). The mean (± s.d.) ψ at presentation was 40.7 ± 22.6 nmol.μmol ucr–1, compared to 25.4 ± 4.8 nmol μmol ucr–1 in controls. Urinary levels ψ at presentation are significantly related to prognosis, the higher the level the poorer the prognosis. However, when these levels have been stratified according to the corresponding level of serum β2 m, the level adds little as a prognostic factor. © 1985 The Macmillan Press Ltd.