Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

Abstract

The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CDS molecules, including nonmature CD4+CD8+ thymocytes, and is not caused by anti-idiotype cells. © 1988 Nature Publishing Group.