The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis

Abstract

Background: Colony-stimulating factor 1 (CSF1) and Jun dimerization protein 2 (JDP2) regulate osteoclastogenesis, but a molecular interaction between the two has not been reported. Results: CSF1 up-regulates JDP2 by inducing T-box 3 (Tbx3) binding to the JDP2 promoter, and suppressing Tbx3 expression impairs osteoclastogenesis. Conclusion: Tbx3 is a target for CSF1 in osteoclasts. Significance: Novel molecular targets for CSF1 in modulating osteoclastogenesis are described. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.