Total synthesis of nortopsentins A-D, marine alkaloids

Abstract

Nortopsentins A-D, antifungal 1,4-bisindolylimidazole marine alkaloids isolated from a sponge, were synthesized through palladium-catalyzed cross- coupling of 3-indolylboronic and 6-bromo-3-indolylboronic acids with halogenoimidazoles as the key reaction.